I'm a pretty big guy and I shoot a S&W 28 and SIG 226.
I've never held one but I would imagine the Coonan Arms .357 Mag. auto with it's long cartridge length would also make it easier to hold for a guy with big hands... not cheap though.
The 226 may be too small for his finger but I don't think he will have any issues with any of the large frame S&W revolvers.
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