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Less collateral damage when using a single projectile versus a scattergun.
Less stopping power.
There's advantages and drawbacks.
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If it is in a house you should see how little damage 12 gauge bird shot does after it passes through 2 layers of sheet rock (like the wall of your home) when compared to a 45. Then you break out buck shot and slugs and you can see that a 12 gauge is much more versatile in what it is capable of.