I would consider three things:
1. Mode of carry -- If you pocket carry, make sure the Sig will fit into your pocket (with a pocket holster). If you plan to carry with a belt holster, it shouldn't matter.
2. Fit in hand -- I'm okay with my Colt Mustang but people with big hands just may not like the smaller Colt.
3. Caliber -- As my signature line indicates, a bigger hole is a better hole. Yeah, I know the bullets are the same diameter but you'll get better expansion AND adequate penetration with the 9mm. There are a couple of decent expanding .380 rounds but penetration is less than ideal. I usually carry FMJ in my Colt for that reason (and often carry my Kahr 9mm with hollow points in my pocket).
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