newshooter, welcome to TFL...you'll find there are a ton of smart people on here who have a world of experience you can learn from...and be prepared for plenty of opinions and preferences
choosing a handgun is a very personal thing...everyone has their preferences...but, there are some very popular guns out there (Glock, S&W, Ruger, etc, etc)...if you can, make sure you at least get to hold a CZ...I have the CZ 75 SP-01 Tactical and it's the best feeling gun in my opinion...reliable, low recoil...and, it's also one of the most accurate on the market
in my opinion, shooting a 22 is great for about 10 minutes but then gets boring...I prefer to shoot what I would use in a real-world situation since the recoil on a .22 differs considerably from a .40 or 9mm...for a first gun, I lean towards 9mm
good luck
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