[Double Naught Spy]

In short, yes. You can use either hand or secure the slide with both hands and let somebody else pull the trigger when the gun is pointed in a safe direction. Don't load more than one round into the gun. Make sure no part of you is in front of the muzzle.

Missing from my previous post was the word 'sight.' If you don't trap the slide fully and you are holding the gun bare handed the slide moves within your grasp, the front sight passing through your grip will be painful. You don't want it recoiling across your palm or fingers.