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You are talking buying ammo, so now I'm going to assume you don't reload.
The 243 will be cheaper and easier to find then the 6.5X55.
The 6.5 will have more recoil but I don't think it would be objectional.
Both are excellent rounds.
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Kraig Stuart
CPT USAR Ret
USAMU Sniper School
Distinguished Rifle Badge 1071
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