This discussion illustrates exactly why I bought my Single Six in the 9.5" barrel. I wanted a .22 squirrel/rabbit/groundhog gun that would take maximum advantage of the ammo I put through it. It's not a tack driver like my semi auto target pistols, but a head shot at 25 yards is no problem. It likes CCI Maxi-Mag 40gr hp's, and the Mini-Mag 40gr rn's in the .22 cyl. Surprisingly, it shoots the Remington Viper hyper velocity .22 very well also, but I haven't seen this since I bought a value pack of 5 boxes with a free knife for $10.
