For 500 yds on big game from a 30-06 class cartridge, I would say 280 Remington or (of course) 30-06. Tolerable recoil and enough OOMPH! to do the job well and kill cleanly.
For "unusual", you can go with 240 Weatherby, 6mm-06, 7X57mm, 7X64mm Brenneke, 7mm STW, 7X68mm, 30 Gibbs, 30-378, or any one of dozens of wildcat or proprietary chamberings (my favorites are Lazzeroni or Hawk).
In magnum chamberings, 7mm RemMag/7mm WSM, 300 WinMag/300 WSM. Or, if you like really loud and lots of recoil, 300 Weatherby/300 RUM (virtually indistinguishable from one another, performance-wise).
In big bores, 338 WinMag. Few other big bores can do it without punishing you. If pain is desirable, you really can't beat a 378 Weatherby for killing out there and maiming right here.
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