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A 22mag is ok if you know what your doing and know how to place your shot.
(a 22 through a tear duct is better than a 45 in the arm, Jeff Cooper).
I sometime carry a S&W 650, 3 inch barrel for deep cover. We all know that shot placement is paramount. Put a 22mag round in the right place and you're ok.
That being said, be sure you know what you're doing and have the training to keep your calm while you make the shot.
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