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the G22 has it all over the G21 UNLESS you're looking at running +P or .45 Super
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that is highly subjective. the 40 may have higher velocity and more FTLBS at the muzzle than the 45 but it also loses speed and energy faster over range. at 50+ yards a 230gr FMJ 45 overtakes a 180gr FMJ 40. granted these are outside most peoples shooting distance and well outside HD ranges but the statement that any standard 40 round is superior to a standard 45 round is complete bogus.
all references to velocity and FTLBs are based off ATK ammo charts at federalpremium.com