I have a Super Redhawk in 480 Ruger with an Ultradot on it. It's a joy to shoot and very accurate.
I recently picked up this Ruger Super Blackhawk Bisley Hunter in .45 LC. I put a Leupold 2x Handgun scope on it, and it is very accurate at 50 yards. I think I prefer a red dot sight though, and will try that next.