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I am presuming the interference is at the back end of the cylinder. If that is the case, you need to get the cylinder trued up. Blackhawk cylinders, at least .45 Colt, are often too tight. I had the same trouble with handloads using 300 grain hardcast. I sent my cylinder to cylindersmith.com. Problem solved. You can buy the tool yourself from Midway and others, or take it to a gunsmith. Good shooting.
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