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A .45 Colt with a 300 grain plus hard cast bullet, with a decent meplat, and a hot load, will kill anything on earth with half, or less, of the "power" of a rifle bullet that can't come close to humanely killing "anything on earth." Wound characteristics of rifle bullets are typically different than handguns. Relying on expanding bullets and a handgun is a challenge as rifles have the velocity to destroy a whole lot of tissue with an expanding bullet, whereas the handgun can't match that. But again, a .45 Colt, loaded as noted, will easily out-penetrate any rifle using an expanding bullet.
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