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I'm not a Hornet loader or shooter so I can claim no particular expertise in that regard but based upon game I have observed shot with various calibers including hot .22s I have a suggestion. In the bigger .22 centerfires I'd grab 60-70 grain controlled expansion bullets and go for all the speed I could get..... but the Hornet is going to have stabilization problems with heavy bullets so I would take a different tack. I'd try 50 grain bullets loaded just hot enough for good accuracy, or I'd take the standard Hornet 40 grain softpoint and load DOWN to around 2000-2200 fps. My reasoning is to avoid tearing those little bullets apart-slowing them down will help them expand but hang together so that they penetrate.