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Regardless of the effects of certain psychoactive drugs, there are certain circumstances under which the human body simply will no longer function properly. If someone loses enough blood, they will pass out. If a bone is broken, then the appendage in which it lies can no longer function normally. Whether or not someone feels pain or realizes that they've been injured, the fact of the matter is that they are still injured. If they are injured severely enough, then no amount of mind-altering substance can overcome it.
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