I don't think they'll do it. I think the pressure level is beyond what Ruger considers a safe threshold for the frame/cylinder. (Just an opinion, I have absolutely
zero data to back it up.)
I used to be gung-ho about a Single Six in .327 Federal. ...But I have the Blackhawk and GP100, now. Although I might be able to find a way to squeeze a S&W or the SP101 into the family, I don't think I'd go for the Single Six (without having quite a bit of excess "gun money").
I mention that, because I think quite a few shooters are in the same situation. They scratched the .327 itch (with a Blackhawk, SP101, GP100, or one of the other offerings), and would have to do some work to convince themselves that they can justify the Single-Six as well.
I don't see Ruger offering one. Maybe U.S. Firearms will.