I do it all the time.
I have an on-going test right now, with some ammunition that has been tumbled for 28 hours. When I feel that it has reached an adequate point for testing, I'll shoot most of it, and pull the bullets from a few cartridges to inspect the powder. I don't expect anything out of the ordinary (other than sparkling-clean case walls inside the case).
Tumbling with lead bullets, however, will pick up abrasives in the media. It can get a little messy, and you probably don't want to send abrasives down your barrel intentionally.
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Don't even try it. It's even worse than the internet would lead you to believe.
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