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I have never had a problem substituting magnum primers for regular primers in rifles. I reload .257 weatherby, 30-06, 22-250 and 7mm rem. mag and usually use magnum primers for all of them. Like was said before though, always start on the low side of the publisehd data and work your way up, checking your cases after each fireing.
I think primers are a little like powder and bullets in that if you try a few different ones, you may find one that your rifle likes best as far as accuracy goes. I have found that primers dont' make as much of a difference as the others do though.
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