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The 22-250 cartridge with a good bullet is entirely capable of killing deer. Whether the shooter is might be a different story. I'd feel a lot better carrying a 22-250 for deer than a .357Mag pistol. But that's just me, I guess.
My first centerfire was a 22-250 Rem Mod 788 and I used it to shoot everything I hunted back then. Killed several mule deer and lots of coyotes and lots and lots and lots of ground squirrels. My load for everything was a
55gr Speer and 38.0gr of H380 - Bruce Hodgdon's personal load. Nowadays I'd go for one of the heavier premium bullets for deer.
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