Get close enough and even blanks can be lethal. I have taken down many wasp nests using a muzzle loading 12 gauge loaded with nothing but powder. Just hold the muzzle about a foot away from the nest, pull the trigger, and the nest and all the wasps are gone. No trace except maybe some goo splattered on the rafters of the barn.
On the other hand, get far enough away, and even lead shot loses its lethality.
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