Aqueos,
I think it all comes down to compromises. Can you actually carry such a powerful gun on a regular basis or would it be too large or heavy? What if you missed? How quickly could you get off a second shot? Are you going to suffer permenant hearing damage if you fire the gun an enclosed environment? What about over penetration or the huge muzzle flash that gives away your location?
While the common handgun cartridges have failed to "immediately stop" an attacker, many well placed gun shot wounds will stop the fight pretty darn quick. People do some pretty amazing things in life or death situations. Choose good ammo in a good gun and you probably won't go wrong.
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The ATF should be a convenience store instead of a government agency!
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