It takes a lot of practice to obtain the proper presentation where by the time you punch out the pistol, you'll have the sights properly aligned on target.
Otherwise, in defensive situations (i.e. really close up), you can shoot from a 'half-draw' (whereby you draw the pistol, rotate your elbow downwards, and bring the muzzle to bear--without bringing the pistol to your centerline or 'punching' the pistol out) and still make good Center-mass shots. I occasionally practice like this.
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