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For deer, with the '06, I've used 52.5 grains of IMR 4064 and a 150-grain bullet since 1950. Accuracy has not varied with different bullets or primers, nor in different rifles. I've always managed to get inside one MOA for three-shot groups.
Shooting at a steel plate at 500 yards, there is a noticeable difference in "damage" between the 150-, 165- and 180-grain bullets. (All loads were with 4064.) For elk, being otherwise ignorant, I would choose the 180-grain.
In my rifle, there is an almost-negligible difference in point of impact among these three loads with a sight-in of 2" high at 100 yards.
FWIW, Art
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