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Originally Posted by Mike / Tx
Probably the biggest issue you will face will be whether or not they will fit the chamber well enough for reliable function.
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Absolutely correct.
Let's think about this for a minute. Do you think the bullet knows where it is sized? Whether it's run through a sizing die or is sized when it hits the throat? I like to run my cast bullets just a tiny bit oversized to make sure that I get a good fit in the bore. Most of the bullets I shoot in handguns (whether revolver or semi) are shot as-cast. As long as the cartridge will chamber well enough for reliable function, I don't bother with sizing.