Perfomance wise, if you reload, you can make the .22-250 into a .223,but you'll never make the .223 into a .22-250. You'll get more than 50yds over the .223 as well.
Unless you are carrying ammo by the 5 gal. bucket into a prarie dog town, go with the .22-250. I have one in a 788. Just awesome.
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