if there caught in a leghold trap or snare and you could get em right between the eyes every time then sure.
Of course if you have to pepper the poor yote with 3-5 shot to kill it your hide is as equally downgraded.
Invest in a few of these and save your bullets maybe? No bullet holes whatsoever, and if you set it right it kills em quick and humane.
I was in the same boat with beavers, a rancher had a hole mess of them along his creek and I figured some hides would be nice, my partner had a 22 browning and I had a little lever gun in 38 special with some cast bullets, loaded fairly mild.
He got himself a couple hides with a few to several 22 holes in them, while the 38 made ONE 3/8 of an inch hole and put em down quick and humanely, and the holes get sewn up anyways.