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Is a full metal jacket round better than JHP for game with with heavy coats of fur & hide and skulls of thick bone?
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Yes, in a defensive handgun bullet. You've got to have penetration FIRST, or expansion is meaningless. But a bonded or partition bullet - overall construction - with a JHP or without - is even better than FMJ/Ball. Then you get as good or better penetration than FMJ, AND at least some expansion.
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In other words, is penetration a much more important issue with big mammals than with human beings?
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Yes.
P.S. Black bears will run away from you, usually before you ever see them. A brown bear may or may not, but a standard defensive round handgun (9mm, .40, .45, etc.) is going to be next to useless against such a mighty creature - much better off relying on pepper spray if you don't have a .44 magnum or bigger, and even then you're probably better off relying on pepper spray.