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I have worked up loads using whatever primers were available starting at the minimum safe load of course.
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Well, I didn't even do that (go to minimum). My loads are light/medium, so I knew the primer shouldn't be to much of a factor. So I went out and proved that with the powders I was using. For example with Unique I found back to back :
.45 Colt
8.5g Unique, 255g SWC, CCI-300, 977fps, 17 SD, 56 ES, 15 shots
8.5g Unique, 255g SWC,
CCI-350, 985fps, 21 SD, 82 ES, 15 shots
or with TB.
.44 Spec
5.2g Trail Boss, 255g SWC, CCI-300, 756fps, 12 SD, 57 ES, 30 shots
5.2g Trail Boss, 255g SWC,
CCI-350, 765fps, 11 SD, 54 ES, 29 shots
Now with TB and the .45 Colt I found under
one bullet magnum primers were twice as consistent (half the SD) than the regular primers. Go figure. So sometimes I'll test with both just to see....
If you are working at the 'bleeding' edge definitely back off, say 10-15% and work back up when trying an unknown primer (to you)....