I think the 22 mag would be great in a rifle. Handgun ballistics leave a lot to be desired.
The muzzle blast from these shells in a handgun would cause a lot of damage to you. It's far worse than some larger calibers. The only real advantage of the 22 mag would be in countries where centerfire handgun ammo is restricted, times when you need to carry a LOT of extra ammo for your pistol, or you need an eight shot Taurus compact revolver with a 3 or 4 " bbl.
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