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I think it helps to look at why other handgun cartridges are popular...
The .38 special, .357 mag, 9mm, .40 S&W and .45 ACP have all, at one point or another, been adpoted by either law enforcement or the military on a large scale. Even the .380 and .32 were popular European military and police cartridges for many decades.
I can think of only one big exception in the handgun world, the .44 magnum, however, it's my understanding that it didn't not become widely known outside of shooting circles until the Dirty Harry series. You can't understate the power of Hollywood.
Otherwise, Glock supports this round with moderately priced guns that can be found without much trouble.
Oddly enough, the .45 GAP is to the .45 ACP what the .40 S&W is to the 10mm and hasn't taken off.
The 10mm won't go away, though. It offers magnum level ballistics with moderate recoil for it's class and good magazine capacity. The guns can also be easily converted to the popular .40 S&W with just a barrel change.
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