Some are unreliable, some aren't. There have been more .22 semi-autos made throughout history than anyone would care to count, some have been junk that I'd hesitate to accept even as a free gift, and others quite the opposite.
"General wisdom" suggests the .22 semi-autos tend to be less reliable. In a way this makes sense, since dealing with semi-auto pistols, most pistols that aren't .22's fire cartridges specifically designed for use in semi-autos, with .22lr this isn't the case. There's a greater variety in .22lr loadings available than just about any pistol caliber, not all of them work in a semi-auto.
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"My momma, she done told me, there's heart and then there's hate
If one of 'em's inside of you, the other one, it aint."
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