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Both calibers will do just fine. Which do you shoot/feel better with? I have hunted antelope with every thing from old military rifles (bolt, breech, semi auto), handguns, and modern bolt guns. Have been kicking around the thought of taking my 45 Colt lever action with the appropriate loads, antelope hunting. I live in WY, so yes, you have to learn to be sneaky. Happy hunting. Ralph
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