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Smokey92,
I use 120gr 777 (weighed) with a 245gr tipped copper Powerbelt in my 50.
I use 105gr 777 (weighed) with a 195gr tipped copper Powerbelt in my 45.
My last buck I took with the 45 at just over 100yrds and it blew a baseball size hole out the back side. The Powerbelts are BAD!
I spent a lot of time playing with different loads and bullets.
The 50 setup (120/245) works so well that a friend of mine bought a CVA Optima Elite (same barrel as my Optima Pro) and grabbed a few of my speed loaders and the first 5 shots had 4"-5" groups at 50 yards. (open sights)
But like I said, I go against conventional wisdom and I weigh all my loads.
I like the consistency I get with weighed charges vs volume.
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