I have 125 grain Critical Defense in my 4 inch SW66 bedside/sometimes carry gun. I have 38+P Critical Defense in my always carry pocket gun. In fact I had 40SW Critical Defense in my semi auto when I kept that loaded. From what I have seen in tests and read in reviews the polymer tip works well to make sure the bullet always expands.
Here tnoutdoors9 does a gel test with
357 Critical Defense.