The 0-6 is bigger and is better suited for larger game. e.g. moose, elk. Some even say it is fine for grizzly bears.
It is very versitile to load. I load mine 'down' for smaller game and closer ranges. Mild recoil that way and less ruined meat.
The .308 is a fine caliber that will do almost as much as the proven 30-06.
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