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I posted a response from a guy at Sierra about bullet design in general. The gist was that there is an effective range where a given bullet performs best.
For instance, some will blow up if the target is within 100 yards and the muzzle velocity is above 3,000 ft/sec. That bullet would do well for longer ranges. (They referred to their 150-grain boat-tail; that might also be the case for such as the SST 150-grain.)
The 165- and 180-grain bullets are somewhat "tougher" and are less likely to blow up. They provide greater penetration. A 180-grain would be effective throughout any probable hunting range. The downside would be recoil and possibly trajectory.
Overall, when in doubt, contact the manufacturer. Most have websites, and I imagine all of them will happily respond to email, although that might take a day or so, depending on the question.
Regards,
Art
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