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I'm getting a big bore low pressure revolver for home defense.
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Well, for starters, a big slug that is effective, no wear on the gun, easy to shoot, low blast/muzzle flash/noise, easy to handload...and if you want to push it a bit...
I have some faith in this guy's testing and conclusions (Taffin):
http://www.handloads.com/articles/default.asp?id=12
And this guy is no slouch either (Linebaugh):
http://www.customsixguns.com/writing...g_the_myth.htm
My 4" M25 is one of the last revolvers I would ever part with.