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I didn't check out the size of the 650 but from what I remember it's one of Taurus's medium or larger frame revolvers which would put it in the mid to high 20's ounce-wise. I would think your wrist would be fine shooting 357s (maybe not 50 or more at a time - but then your wallet will be sore, too). The thing to worry about would be the gun itself, the more pop the round has the more chance there is for damage like putting the timing off, etc. That is true for any gun, not just a Taurus. That's why they designed beefier framed revolvers when the 357 mag was developed. But unless there is a problem, there shouldn't be any damage for hundreds, maybe thousands, of rounds. If everything checks out initially it may take a while for any problem to develop.
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