Ive been doing it 18/7/365 for about 35 years now, and find it to be the most comfortable and concealable way to wear a gun.
Ive done it fat and skinny, and never really changed how I dressed. I wear the same size pants I would normally wear, a tee shirt, and usually an untucked shirt or sweatshirt/fleece, depending on the time of year. Ive even carried a Colt Commander and a double reload under a tucked in oxford dress shirt for awhile when I had to dress up (doing that was far more uncomfortable than wearing the gun ever was
).
As others have said, get a good belt and holster, find your "spot", and give it a good chance (it doesnt take long), and you soon wont know its there.