I really don't think of 4.3 of Unique as a very LIGHT load. Not heavy, with az 125 bullet, no, but not heavy.
Unique and the other quick-burning powders need a firm crimp. Combination of old brass (weak tension, as mentioned) and little or no crimp might result in incomplete ignition, with attendant unburned powder granules.
I've loaded many thousands of cast and swadged bullet rounds with old Unique, which can be a fairly dirty combo, and have never experienced the problems you describe. Not even after 200--300 rounds without cleaning. But, early on, I'd been told about brushing out under the extractor star whenever cleaning, so that, with a light crimp, may be the cause of your problems.
If you continue to have difficulties, we can work out a way for you to ship your revolver and all your components to me, so I can do a detailed study of the matter. Shouldn't take more than six months or so. No charge. I just like to help out.
Best,
Johnny