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Zip experience with anything Barnes except their 165 XBT in .30 cal at 2400 fps.
"Good enough" accuracy = ~1"++ 3-shot groups at 100 & no signs of tipping past 300 yds. 300 yd groups around 4-5", & some of that's me. My "low-velocity" bullet of choice for elk.
Ballistic Coefficient is very high due to the added length-for-weight, but as you mentioned, a bit of a internal case volumne loss associated.
All mine's been rifle-stuff ... & with excellent results.
Too, I've heard of the bullets not obturating to the rifling due to the "hard" cpper/solid bullet. The metal is annealed to proper hardness & does - all have full-groove rifling that I've shot.
As with any compenent change, always work up from known data.
Actually, for a .44/.45 cal-class handgun I'd not spend the big $s using such a premium bullet, unless for a .44 special level SD loading, or similar. A hard-cast bullet will shoot through almost anything reasonable & kill it just as dead as a $.50 bullet will.
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