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Going with calibers larger than that - .454, .460, .500 - usually means carrying a much larger gun that will weigh you down. They're also not a practical choice if you're mainly worried about 2-legged critters.
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The extra big frames and extreme cartridges,for me,are conducive to flinch,and big enough to leave behind.
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I also have to agree with those two statements completely. Standard cartridges and packable sixguns will do 99% of what needs doing.