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The higher the speed, the quicker the bullet expands in the target. Look at the gello results above, and you'll see that 180 grain bullet, 44 magnum, transfers energy into the gello on impact that the 45 ACP can only dream of.
Given proper bullet construction, the 44 magnum is so far beyond the 45 ACP that the wounding mechanism changes, approaching rifle effects.
The only real world shooting with a 44 on a human was an Arizona DA. And yes, it did exactly what Harry Callahan said it would do, using a glasser safety slug. The BG pointed a rifle at the DA...
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