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Well, I'm going to go the other way. My two hunting calibers are 375 H&H, and, 30-06.
If you hand load, the cost factor advantage of the 30-06, .308, become much less. I'd try and find what caliber is going to give me an expanded bullet, that leaves two big holes, through the size game I'm after. 375 is not known for a tremendous amount of meat damage, but, it has killed everything on the planet. At your ranges, you could look in to 45's. I'm going to go from 375 to 458, simply because I like large holes in things I shoot. Given the right bullet, you can
have a long range 450 Watts, or, a short range stopper.
There is a well documented effect that 500 grain bullets just tend to numb things, where lighter bullets don't.
With a good reloading setup, you can go mild to wild, with the bigger calibers.
However, no one makes mil surplus ammo, like the 308, or 30-06, and, you do have to love reloading to do it.
Heck, for the size deer your talking about, you could probably use a 223, with the right bullets...
S
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