If your goal is the ability to put the weapon into action quickly then there is no advantage to chamber empty carry
If your aim is "safety" (or the illusion therof) then chamber empty may be an advantage
I know people that carry chamber empty on a DA auto....I have no idea how you accidently fire a weapon with a 12 lb trigger (unless you have your finger on it ) but it makes them feel better
All handguns are safe in a good holster
Where problems occur (generally) is in gun-handling
Drawing, holstering, etc.
What I worry about is people training one way and carrying another
Even those people that I know that carry unchambered weapons practice with "one-in-th-pipe"
They are not unloading the chamber after every string
So they generally get very little practice in actually employing the weapon
And very few people practice one hand shooting enough let alone one hand manipulations
Despite the fact that a great many gun-battle injuries are to the hands because of the tendencey to "tunnel in on the weapon"
And I know of nobody that carries a revolver with the next hole empty...I wonder why that is