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I was having the same problem. I like H4350 for it but it was nowhere to found. I've found H414 works very well and has done so apparently for the last 40+ years (according to other reloaders I've talked to). Also Superformance powder has been readily available I guess due to the lack of data for it but it's by far the best powder for getting the 22-250 well past the 4000fps mark, this stuff is nothing short of amazing!
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