The shotgun slug was invented just to prove that it's possible to create a projectile that has an even worse ballistic coefficient than a roundball shot from a muzzleloader.
Twelve gauge slugs going 1600 fps out of the muzzle will be down to about 800 fps, more or less by the time they fly 100 yards through the air.
The much more aerodynamic 405 grain .45-70 bullet shot with a 1600 fps muzzle velocity will still be going 1300+ fps at 100 yards.
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