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I have no hard data to go on, but my guess would be that with a .380 you would do as well by shooting center of mass as you would any other target, but you probably are going to have to put more rounds on target than with a heavier centerfire caliber. With a .22 or .25, I would not be confident in getting a prompt stop with chest shots. My thought would be to shoot at the face so that the shots would be something to slow and distract the assailant and maybe get a psychological stop even if you didn't get a hit that made a physiological stop.
I am willing to be educated if someone has some data that would cause me to adjust my thinking, though.
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