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Offhand I can't recall ever having a centerfire primer fail to go off. I don't reload (my understanding is reloads can be finicky), but I put a couple thousand rounds of relatively cheap (winchester/remUMC) target loads downrange a year. .22 failing on the other hand is a semi-regular occurrence.
I'd second all the above opinions that I'd rather have a .22 than nothing, but if you're choosing a weapon specifically for HD, it seems like a bad option. I know from personal experience that hitting a deer is significantly harder than hitting a paper circle, and I can imagine that hitting a person in the head - presumably in low light after having just woken up - would be very hard indeed. Buy a pump shotgun: sounds scary, looks scary, is scary.
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