I can tell you from personal experience that a solid sternum hit from
the venerable .45acp is not always the manstopper that some internet
gun experts would have you believe. In my case, the individual didn't
appear to react at all to being hit. I would choose the largest caliber
that I could shoot accurately. I have moved on from carrying the
.45acp and now carry the .357 Sig. Hopefully, it will never be needed.
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